Cleaning is the primary product in short batch campaigns
Batch reactors limit your chemistry scope and yield
Slow heat & mass transfer requires cryogenics, limits throughput, and creates impurities
Discontinuous processes result in large inventories, labour and overhead costs
Yet, batch is simple and versatile
Our reactor combines benefits of both flow and batch
Benefits in brief
Our reactor improves and simplifies a series of stirred tanks providing all the benefits without their complexities. You already know about batch hydrodynamics – these all apply to our reactor.
Many impellers in small chambers maximise heat & mass transfer for excellent reaction control, high yield, simple reaction cascades and expanded chemistries (exothermic, labile, explosive). The reactor is configurable in minutes for various impellers or reactions. You save on materials, overheads, and labour.
Rapid adoption & process development
Flow chemistry would be simple if you could apply all the knowledge from batch directly to flow. You can now!
Our reactor is an improved series of continuously stirred tank reactors (CSTRs) with familiar impellers. Our studies show that all the correlations in hydrodynamics, heat and mass transfer derived for batch reactors still apply. Such predictability removes the adoption risks, accelerates, and simplifies process development.
Multipurpose – convert any batch to flow
Any batch process can be converted into flow; liquids, gases or solids in any combinations. Examples include cross-coupling (liquid), homogeneous hydrogenation (gas-liquid), heterogeneous hydrogenation (gas-liquid-solid), extraction (liquid-solid), crystallisation (liquid with solid formation), polymerisation (high viscosity), emulsions (viscous multiphase), and more. Our reactor can handle slurries as thick as 30 wt% with up to 0.15 mm particle diameters.
Impellers or reactor volume can be changed within 15 minutes, reducing risks and saving costs and time.
Simplified reaction cascades
The Stoli reactor allows feeding of additional reagents at any point in the vessel – at any chamber. And it can sparge them across several reactor chambers.
Telescoping synthesis becomes possible in a single reactor. Several reaction steps, or reaction with initial workup, can be combined for process intensification to use time, equipment and premises at peak efficiency.
Opens new chemistry routes
Excellent control of the reaction parameters and accelerated reaction cascades enable feasible and scalable use of hazardous, energetic or labile intermediates.
Intermediates can be obtained in-situ and rapidly consumed, reducing the process risks while opening new chemistry opportunities or reaction shortcuts. As a result, synthetic routes can be shortened and available reagents used.
Precision & Control
Our reactor has multiple impellers in small compartments to enable rapid heat and mass transfer and handle even rapid chemical processes. At any feeding flow rate, the Stoli reactor enables rapid heat and mass transfer for high yield and product selectivity.
Residence time (the time chemicals spend in the reactor) and its distribution can limit the process range and performance. In our reactors, the average residence time can be seconds to hours with the distribution narrower than a series of 10 ideal CSTRs. The distribution is often quasi plug-flow with negligible backmixing to control the yield and impurities.
Reliability and cleanliness
The polished reactor surface traps little impurities and it is fast to clean. Our design is focused on FDA cleanliness standards with polished surfaces and no dead zones. The components can be cleaned in place or removed in 15 minutes for thorough external cleaning. Reactor cleaning turnover can be as fast as 30 minutes.
Our innovative reactor design incorporates the benefits of multiple continuously stirred tank reactors (CSTRs) into a single multi-chamber reactor with a single stirring motor. This removes the need for complex fittings, extra pipework and multiple reactors with dedicated motors – a simple and reliable design.
Hastelloy® C276 / Kalrez / PTFE
316L Stainless steel/ Kalrez / PTFE
Glass / Hastelloy® C276 / Kalrez / PTFE
|Temperature||-40 to 250 °C (3 temperature zones as an option)|
|Pressure||Vacuum to 20 bar (100 bar option)|
|Residence times||0.5 to 300 minutes|
|Cascade reactions||Main liquid feeding with 2 side-feeding arms for reagent sparging or addition to a specific chamber|
|Reactor volume||3 reactor options are available at lab (15-100 mL), kilo (0.15-1 L), and pilot (1.5-10 L) scales|
|Stirring rates||10-1500 rpm (compatible with existing overhead stirrers)|
Overhead stirrer (IKA)
Heating fluid circulator – heating or heating/cooling (IKA)
Fluid feeding and metering with Bronkhorst flow controllers and meters; 0.1 mL/min to 10 L/min liquid flow, 1 mL/min to 30 L/min gas flow
Back pressure regulation (Fixed or variable)
Expertise & Excellence
Established in 2016 as a Warwick University spinout, we capitalise on our extensive expertise in heterogeneous catalysis and flow chemistry.
Our excellence has been recognised by receiving numerous awards and highly competitive grants such as a £500k Innovate UK grant, participation in the Royal Society of Chemistry Emerging Technologies competition and the award of a Royal Academy of Engineering Enterprise Fellowship.
We are currently scaling-up the continuous manufacturing (with a €1.2M Horizon 2020 SME Instrument grant #848926) to provide sustainable manufacturing of chemicals at a lower manufacturing costs.
Our intern, Omar, gives advice to graduates on how to secure an internship.
We have a new opening – check out!
Online calculator to estimate how much energy could be saved with flow chemical manufacturing
Visit us and see our new Scalable Agitated Baffle Reactor (SABRe) at CHEMUK2021, NEC Birmingham, stand B25 September 15th-16th
Dr Sam Adams from Stoli Catalysts discusses why the batch technology dominates, introduce the flow chemistry, and discuss problems & opportunities in switching to flow.
SABRe shows a factor of 1.75 higher throughput in a reaction limited by heat transfer.